Journal ArticleDOI
IVD progenitor cells: a new horizon for understanding disc homeostasis and repair
Feng-Juan Lyu,Feng-Juan Lyu,Kenneth M.C. Cheung,Zhaomin Zheng,Hua Wang,Daisuke Sakai,Victor Y. L. Leung +6 more
TLDR
Whether and how IVD degeneration and the hostile microenvironment might affect endogenous progenitor cell function are considered, and ways to channel the potential of these cells for IVD repair are suggested.Abstract:
Intervertebral disc (IVD) degeneration is associated with low back pain. In IVDs, a high mechanical load, high osmotic pressure and hypoxic conditions create a hostile microenvironment for resident cells. How IVD homeostasis and function are maintained under stress remains to be understood; however, several research groups have reported isolating native endogenous progenitor-like or otherwise proliferative cells from the IVD. The isolation of such cells implies that the IVD might contain a quiescent progenitor-like population that could be activated for IVD repair and regeneration. Increased understanding of endogenous disc progenitor cells will improve our knowledge of IVD homeostasis and, when combined with tissue engineering techniques, might hold promise for future therapeutic applications. In this Review, the characteristics of progenitor cells in different IVD compartments are discussed, as well as the potency of different cell populations within the IVD. The stem cell characteristics of these cells are also compared with those of mesenchymal stromal cells. On the basis of existing evidence, whether and how IVD degeneration and the hostile microenvironment might affect endogenous progenitor cell function are considered, and ways to channel the potential of these cells for IVD repair are suggested.read more
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Journal ArticleDOI
Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions.
TL;DR: In this paper, an overview of the advances in inflammation-related pain in disc degeneration is provided, with a discussion on the role of inflammation in IVD degeneration and pain induction.
Journal ArticleDOI
Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019
TL;DR: In this article , the authors comprehensively analyzed the global level and trends of prevalence, incidence and years lived with disability for low back pain (LBP) from 1990 to 2019 by age, sex and sociodemographic index (SDI).
Journal ArticleDOI
Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019
Sheng Chen,Sheng Chen,Zengwu Shao,Mingjue Chen,Huiling Cao,Huiling Cao,Xiaohao Wu,Sixiong Lin,Sixiong Lin,José Costa,José Costa,Chu Tao,Huiling Cao,Zengwu Shao,Guozhi Xiao +14 more
TL;DR: In this article, the authors comprehensively analyzed the global level and trends of prevalence, incidence and years lived with disability (YLDs) for low back pain (LBP) from 1990 to 2019 by age, sex and sociodemographic index (SDI).
Journal ArticleDOI
Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering.
TL;DR: How recent research has tried to overcome the obstacles coming from the IVD microenvironment by developing innovative cell therapies and functionalized bioscaffolds is focused on.
Journal ArticleDOI
Substrate stiffness- and topography-dependent differentiation of annulus fibrosus-derived stem cells is regulated by Yes-associated protein
Genglei Chu,Zhangqin Yuan,Caihong Zhu,Pinghui Zhou,Huan Wang,Weidong Zhang,Yan Cai,Xuesong Zhu,Huilin Yang,Bin Li +9 more
TL;DR: It is demonstrated that larger-sized and higher-stiffness substrates increase the amount of vinculin assembly and activate YAP signaling in pre-differentiated AFSCs, possibly through a YAP-dependent mechanotransduction mechanism.
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TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal ArticleDOI
Epidemiological features of chronic low-back pain
TL;DR: Because the validity and reliability of some of the existing data are uncertain, caution is needed in an assessment of the information on this type of pain.
Journal ArticleDOI
In search of the in vivo identity of mesenchymal stem cells
TL;DR: This model proposes that MSCs stabilize blood vessels and contribute to tissue and immune system homeostasis under physiological conditions and assume a more active role in the repair of focal tissue injury and provides a basis for the rational design of additional in vivo therapeutic approaches.
Journal ArticleDOI
The prevalence of low back pain: A systematic review of the literature from 1966 to 1998
TL;DR: A systematic literature review of population prevalence studies of low back pain between 1966 and 1998 was conducted to investigate data homogeneity and appropriateness for pooling, and a model using uniform best-practice methods is proposed.
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