Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Journal ArticleDOI
Ultrastructural and electrophysiological analysis of Area X in the untutored and deafened Bengalese finch in relation to normally reared birds
Zhe Peng,Xuebo Zhang,Yu Liu,Chao Xi,Shaoju Zeng,Xinwen Zhang,Mingxue Zuo,Jincao Xu,Yubin Ji,Zhongming Han +9 more
TL;DR: The decreased or irregular electrophysiological activity in the untutored or deafened birds, together with the corresponding ultrastructural findings, could be implicated in the abnormal song production in these two types of birds.
Journal ArticleDOI
Thoracic VGluT2<sup>+</sup>Spinal Interneurons Regulate Structural and Functional Plasticity of Sympathetic Networks after High-Level Spinal Cord Injury
TL;DR: In this article , the authors showed that the onset and progression of SCI-induced structural plasticity is neuron activity dependent, and selectively inhibited (or excited) thoracic VGluT2 + interneurons using chemogenetics.
Solving the binding problem: cellular adhesive molecules and their control of the cortical quantum entangled network
TL;DR: The biological basis of interneuronal entanglement is described in the frames of the beta-neurexin-neuroligin model and is proposed novel mechanism for control of the neurons that are temporarily entangled to produce every single conscious moment experienced as present.
Journal ArticleDOI
The Neuroscientist comments
Q. Wu,T. Maniatis +1 more
TL;DR: It is suggested that immunoglobulin-like gene rearrangement may occur within cadherms, which are organized in three closely linked clusters and would provide a powerful mechanism for generatmg diversity m these cell adhesion molecules.
DissertationDOI
Functional study of neuronal calcium sensor-1 (NCS-1) in yeast and mice : a role for NCS-1 in learning and memory
TL;DR: In this article, deux lignees transgeniques de souris (Tg26 and Tg200) were derived, which surexpriment NCS-1 dans des regions restreintes ou etendues du systeme nerveux.
References
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The unbiased estimation of number and sizes of arbitrary particles using the disector
TL;DR: A three‐dimensional counting rule and its integral test system, the disector, for obtaining unbiased estimates of the number of arbitrary particles in a specimen is presented.
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