Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Journal ArticleDOI
A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder
Laura Gennaccaro,Claudia Fuchs,Manuela Loi,Vincenzo Roncacé,Stefania Trazzi,Yassine Ait-Bali,Giuseppe Galvani,Anna Cecilia Berardi,Giorgio Medici,Marianna Tassinari,Elisa Ren,Roberto Rimondini,Maurizio Giustetto,Giorgio Aicardi,Elisabetta Ciani +14 more
TL;DR: In this article, the perirhinal cortex (PRC) of Cdkl5 KO mice was examined and the efficacy of limiting excessive GABAB receptor-mediated signaling in improving synaptic plasticity and cognition in CDD mice was investigated.
Journal ArticleDOI
Decisions, dopamine, and degeneracy in complex biological systems
TL;DR: This review proposes a framework to investigate different aspects of the theoretical and molecular neurobiology of decision-making, and combines aspects of current ideas relating to information processing by the hippocampal formation and how these relate to the phasic midbrain dopaminergic firing that occurs in response to the spatial and motivational aspects of rewarding events in the environment.
Book ChapterDOI
Long-Term Potentiation: A Candidate Cellular Mechanism for Information Storage in the CNS
TL;DR: This chapter reviews long-term potentiation of synaptic transmission, currently one of the most widely studied and popular candidate mechanisms for a cellular phenomenon underlying long- term information storage in the nervous system.
Dissertation
Rôle du transporteur vésiculaire du glutamate de type 3 (VGLUT3) dans la réponse au stress hypoxique néonatal et la surdité DFNA25
TL;DR: L'etude des processus biochimiques mis en jeu nous a permis d'envisager un role indirect of VGLUT3 dans l'activation of the mort autophagique, via la proteine Becline 1 and une possible interaction au sein de the voie de the Culline 3.
References
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Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
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A simple method for organotypic cultures of nervous tissue
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Journal ArticleDOI
The unbiased estimation of number and sizes of arbitrary particles using the disector
TL;DR: A three‐dimensional counting rule and its integral test system, the disector, for obtaining unbiased estimates of the number of arbitrary particles in a specimen is presented.
PatentDOI
Dissecting the regulatory circuitry of a eukaryotic genome
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