Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
More filters
Journal ArticleDOI
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Joshua T. Trachtenberg,Brian E. Chen,Graham Knott,Guoping Feng,Joshua R. Sanes,Egbert Welker,Karel Svoboda +6 more
TL;DR: The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
Journal ArticleDOI
Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
Experience-dependent structural synaptic plasticity in the mammalian brain.
Anthony Holtmaat,Karel Svoboda +1 more
TL;DR: Recent evidence for structural forms of synaptic plasticity in the mammalian cortex involves cell type-specific structural plasticity: some boutons and dendritic spines appear and disappear, accompanied by synapse formation and elimination, respectively.
Journal ArticleDOI
MAPK cascade signalling and synaptic plasticity
TL;DR: This work has reported the involvement of a 'parallel' but distinct kinase cascade leading to the activation of p38 MAPK, which might control distinct forms of synaptic plasticity in the adult brain.
Journal ArticleDOI
Morphological changes in dendritic spines associated with long-term synaptic plasticity.
Rafael Yuste,Tobias Bonhoeffer +1 more
TL;DR: There is no evidence that changes in the morphology of spines after LTP are necessary or sufficient for the induction or maintenance of LTP, but a strong correlation between synaptic plasticity and morphological changes in spines is shown.
References
More filters
Journal ArticleDOI
Critical assessment of the involvement of perforations, spinules, and spine branching in hippocampal synapse formation
TL;DR: In this paper, serial electron microscopy was used to assess the morphological basis for synapse spilitting in hippocampal area CA1 and found that synapse splitting is unlikely to be important during development.
Journal ArticleDOI
Mechanisms of silencing in Saccharomyces cerevisiae.
TL;DR: In the yeast Saccharomyces cerevisiae, heterochromatin-like regions are formed at the silent mating type loci and at telomeres, uncovering a fascinating link between silencing, the nucleolus and aging.
Journal ArticleDOI
Dimensions and density of dendritic spines from rat dentate granule cells based on reconstructions from serial electron micrographs.
Mari Trommald,Gunn Hulleberg +1 more
TL;DR: Distribution histograms and scatter plots of various spine dimensions did not reveal any systematic clustering, suggesting that there is a continuum of spine geometries rather than distinct classes for granule cell dendritic spines in the middle molecular layer.
Journal ArticleDOI
Nucleosome-Mediated Synergism between Transcription Factors on the Mouse Mammary Tumor Virus Promoter
Sebastián Chávez,Miguel Beato +1 more
TL;DR: The role of chromatin in the process of glucocorticoid induction was investigated by manipulating the nucleosome density in yeast strains carrying a regulated histone H4 gene as discussed by the authors.
Journal ArticleDOI
RAP1 protein activates and silences transcription of mating-type genes in yeast
S Kurtz,David Shore +1 more
TL;DR: Analysis of rap1ts strains provides evidence that RAP1 functions in both transcriptional activation and silencing of mating-type genes, and several observations indicate that rap1TS strains are defective in the expression of MAT alpha, whose upstream activation sequence contains a R AP1-binding site.
Related Papers (5)
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more