Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning
Alireza Chenani,Ghabiba Weston,Alessandro Francesco Ulivi,Tim P. Castello-Waldow,Rosa-Eva Huettl,Alon Chen,Alessio Attardo +6 more
TL;DR: In this paper , the authors applied longitudinal deep-brain optical imaging to investigate the link between changes in activity patterns and structural plasticity of dorsal CA1 pyramidal neurons and hippocampal-dependent learning and memory in mice exposed to stress.
Journal ArticleDOI
Shedding light on learning and memory: optical interrogation of the synaptic circuitry.
TL;DR: Recent progresses in understanding the reorganization of synaptic circuits and neuronal assemblies associated with learning and memory are discussed, with an emphasis on optical techniques for in vivo interrogations.
Journal ArticleDOI
Comparing fluctuations of synaptic responses mediated via AMPA and NMDA receptor channels--implications for synaptic plasticity.
TL;DR: The results argue against the glutamate spillover model according to which the effect of glutamate--and hence the induction of plasticity--may spread unspecifically between synapses, and how can silent synapses become functional if no spread of glutamate occurs and no initial signal is present to trigger the functionalization.
Journal Article
Changes of synaptic structure after long-lasting LTP induced by high and low frequency tetanus in slices of the rat visual cortex.
TL;DR: The data suggest that newly formed synapses in the 100 Hz tetanus-induced L-LTP group are larger than those in the 2 Hz group and that 100Hz tetanus might trigger reorganization or synthesis of postsynaptic cytoskeleton.
Journal ArticleDOI
Spatiotemporal summation and correlation mimicked in a four-emitter light-induced artificial synapse.
TL;DR: A mathematical model is proposed based on a convolution operation and nonlinear distortion function to explore the elementary synaptic mechanism of a biological synapse with multiple presynaptic inputs and offers a new approach to building artificial synapse networks.
References
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The unbiased estimation of number and sizes of arbitrary particles using the disector
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