Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
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Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders
Katelyn Cuttler,Maryam Hassan,Jonathan Carr,Jonathan Carr,Ruben Cloete,Soraya Bardien,Soraya Bardien +6 more
TL;DR: Neurexins are one type of synaptic cell adhesion molecule that have, recently, gained more pathological interest and have been associated with several neuropsychiatric disorders, such as autism spectrum disorder and schizophrenia as discussed by the authors.
Journal ArticleDOI
Evidence for constitutive protein synthesis in hippocampal LTP stabilization.
TL;DR: LTP stabilization was impaired by pre- LTP application of protein synthesis inhibition but not by post-LTP application unless the slices were exposed to oxidative stress, supporting the notion that constitutive rather than triggered protein synthesis is important for LTP stabilization.
Journal ArticleDOI
Effects of age and acute ethanol on glutamatergic neurotransmission in the medial prefrontal cortex of freely moving rats using enzyme-based microelectrode amperometry.
Devesh Mishra,Nicholas R. Harrison,Carolina Bengtsson Gonzales,Björn Schilström,Åsa Konradsson-Geuken +4 more
TL;DR: The data demonstrate age-dependent differences in extracellular glutamate levels in the medial prefrontal cortex and suggest that acute ethanol injections have both inhibitory and excitatory effects in adolescent rats.
BookDOI
Suicide: Phenomenology and Neurobiology
Keri E. Cannon,Thomas J. Hudzik +1 more
TL;DR: In the present chapter, concepts and research efforts that will be discussed in detail in later chapters are introduced and encompass the areas of epidemiology and predictive tools, risk factors, and clinical and preclinical neurobiology.
Journal ArticleDOI
Progeny's mental aptitudes in man: relationship with parental age at conception and with some environmental factors.
Maurice Auroux,Magali Volteau,Béatrice Ducot,Thierry Wack,Alexia Letierce,Laurence Meyer,Marie-Jeanne Mayaux +6 more
TL;DR: Regarding the respective influences of the environment and of the subject's genome on his cerebral development, one can hypothesize a complementarity between these two factors through the possibility of a genetically determined individual synaptic potential, revealing itself, more or less, according to environmental conditions.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
TL;DR: DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation of the temporal program of gene expression accompanying the metabolic shift from fermentation to respiration, and the expression patterns of many previously uncharacterized genes provided clues to their possible functions.
Journal ArticleDOI
A simple method for organotypic cultures of nervous tissue
TL;DR: Hippocampal slices prepared from 2-23-day-old neonates were maintained in culture at the interface between air and a culture medium and yielded thin slices which remain 1-4 cell layers thick and are characterized by a well preserved organotypic organization.
Journal ArticleDOI
The unbiased estimation of number and sizes of arbitrary particles using the disector
TL;DR: A three‐dimensional counting rule and its integral test system, the disector, for obtaining unbiased estimates of the number of arbitrary particles in a specimen is presented.
PatentDOI
Dissecting the regulatory circuitry of a eukaryotic genome
TL;DR: The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.
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