Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Journal ArticleDOI
A Common Exocytotic Mechanism Mediates Axonal and Dendritic Outgrowth
Sonia Martinez-Arca,Silvia Coco,Gaëll Mainguy,Ursula Schenk,Philipp Alberts,Philipp Alberts,Pascale Bouillé,Mauro Mezzina,Alain Prochiantz,Michela Matteoli,Daniel Louvard,Thierry Galli,Thierry Galli +12 more
TL;DR: The results suggest that a common exocytotic mechanism that relies on TI-VAMP mediates both axonal and dendritic outgrowth in developing neurons.
Journal ArticleDOI
Experience effects on brain development: possible contributions to psychopathology.
Aaron W. Grossman,James D. Churchill,Brandon C. McKinney,Ian M. Kodish,Stephani Otte,William T. Greenough +5 more
TL;DR: In this article, Waddington's canalization model is used as a tool to conceptualize the interactive influences of genetics and experience in the development of these psychopathologies, which also likely bring about 'organic' changes in the brain.
Journal ArticleDOI
Leptin promotes rapid dynamic changes in hippocampal dendritic morphology.
Dervla O'Malley,Neil MacDonald,Sarah Mizielinska,Christopher N. Connolly,Andrew J. Irving,Jenni Harvey +5 more
TL;DR: It is demonstrated that leptin rapidly enhances the motility and density of dendritic filopodia and subsequently increases the density of hippocampal synapses, dependent on the synaptic activation of NR2A-containing NMDA receptors and is mediated by the MAPK (ERK) signaling pathway.
Journal ArticleDOI
Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities.
TL;DR: The notion that perforated synapses may evoke larger postsynaptic responses relative to nonperforatedsynapses and, hence, contribute to an enhancement of synaptic transmission associated with some forms of synaptic plasticity is supported.
Journal ArticleDOI
Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures
David A. Richards,José María Mateos,Sylvain Hugel,Vincenzo De Paola,Pico Caroni,Beat H. Gähwiler,R. Anne McKinney +6 more
TL;DR: The results suggest that spontaneously released glutamate is sufficient to activate nearby spines, which can then lead to the growth of new postsynaptic processes connecting to a presynaptic site, and thus can compare their recent history with that of neighboring synapses and modify local connectivity accordingly.
References
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