Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Impermanence of dendritic spines in live adult CA1 hippocampus
TL;DR: The results reveal that adult neocortical and hippocampal pyramidal neurons have divergent patterns of spine regulation and quantitatively support the idea that the transience of hippocampus-dependent memory directly reflects the turnover dynamics of hippocampal synapses.
Journal ArticleDOI
Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2
TL;DR: It is proposed that the NTD of GluR2 functions at the cell surface as part of a receptor–ligand interaction that is important for spine growth and/or stability.
Journal ArticleDOI
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.
Eve-Ellen Govek,Eve-Ellen Govek,Sarah E. Newey,Colin J. Akerman,Justin R. Cross,Lieven Van der Veken,Linda Van Aelst,Linda Van Aelst +7 more
TL;DR: It is reported that oligophrenin-1, a Rho-GTPase activating protein that is absent in a family affected with MRX, is required for dendritic spine morphogenesis and an interaction between oligophreitol-1 and the postsynaptic adaptor protein Homer is demonstrated.
Journal ArticleDOI
Brain-derived neurotrophic factor: role in depression and suicide.
TL;DR: Critical evidence demonstrating the involvement of BDNF in depression and suicide is reviewed, suggesting the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior.
Journal ArticleDOI
Mechanisms of Synapse Assembly and Disassembly
Yukiko Goda,Graeme W. Davis +1 more
TL;DR: The current understanding of both synapse assembly and disassembly is reviewed in an effort to unravel the relationship between these fundamental developmental processes.
References
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