Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Expression of the formin Daam 1 in pyramidal neurons of the hippocampus affects spine morphology
TL;DR: Viral vectors were developed using the Semliki-Forest defective viral vector to over-express the full-length Daam1 protein and a DaAm1 lacking the PDZ-binding motif, showing a punctate distribution throughout the dendritic shaft, with the occasional appearance in spines, resulting in an overall increase in dendrite spine length.
Dissertation
Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
TL;DR: My experiments indicate that spine morphology was stable over time with only very little changes occurring following the induction of LTD, and the number of large, prominent spine changes was very low.
Determining the role of Wnt signaling during BDNF-induced cortical neuron growth and dendritic spine formation
TL;DR: It is demonstrated that blocking Wnt signaling in cortical neurons in vitro using four different WNT signaling inhibitors impairs cortical dendrite growth and dendritic spine formation.
Dendritic Spine Dynamics in Retrosplenial Cortex During Spatial Learning
TL;DR: Results from these studies show that contextual learning induces a significant increase in the formation of clusters of new dendritic spines and that the number of new clustered spines correlates with behavioral performance; specifically, animals with the highest proportion of new spines formed in clusters also have the highest context freezing.
References
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Journal ArticleDOI
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Related Papers (5)
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
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