Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Unilateral ischemic sensorimotor cortical damage induces contralesional synaptogenesis and enhances skilled reaching with the ipsilateral forelimb in adult male rats
TL;DR: The improved reaching ability was coupled with an increase in synapse subtypes that have previously been linked to enhanced synaptic efficacy and the failure to induce synaptogenesis in layer V with reach training alone is in contrast to previous findings and may be related to training intensity.
Journal ArticleDOI
The Nogo-66 Receptor NgR1 Is Required Only for the Acute Growth Cone-Collapsing But Not the Chronic Growth-Inhibitory Actions of Myelin Inhibitors
TL;DR: The results provide unexpected evidence that the growth cone-collapsing activities and substrate growth-inhibitory activities of inhibitory ligands can be dissociated and conclude that chronic axon growth inhibition by myelin is mediated by NgR1-independent mechanisms.
Journal ArticleDOI
Trans-Endocytosis via Spinules in Adult Rat Hippocampus
Josef Špaček,Kristen M. Harris +1 more
TL;DR: Spinules engulfed by astrocytic processes support the growing evidence that perisynaptic glia interact directly with synapses at least on thin spines, and trans-endocytosis of spinules by presynaptic axons may provide a mechanism for synaptic competition in the mature brain.
Journal ArticleDOI
Remodeling of hippocampal synaptic networks by a brief anoxia-hypoglycemia
TL;DR: It is reported that brief anoxic–hypoglycemic episodes rapidly modified the structure of synapses, resulting in a profound structural remodeling of synaptic networks, through growth, formation, and elimination of spines and synapses.
Journal ArticleDOI
Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines
Rasha Refaat Mahmmoud,Sunetra Sase,Yogesh D. Aher,Ajinkya Sase,Marion Gröger,Maher Mokhtar,Harald Höger,Gert Lubec +7 more
TL;DR: Correlations between WME and latency in the RAM and spine density revealed a link between spine numbers and performance inThe RAM, and the study shows that spine numbers are significantly increased in the trained group, an observation that may suggest the use of this method representing a morphological parameter for memory formation studies in theRAM.
References
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The unbiased estimation of number and sizes of arbitrary particles using the disector
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