Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Motility of dendritic spines in visual cortex in vivo: changes during the critical period and effects of visual deprivation.
Ania K. Majewska,Mriganka Sur +1 more
TL;DR: It is concluded that spine motility might be involved in critical-period plasticity and that reduction of activity during the critical period enhances spine dynamics.
Journal ArticleDOI
LTP promotes a selective long-term stabilization and clustering of dendritic spines.
TL;DR: Using repetitive confocal imaging on hippocampal organotypic cultures, it is found that learning-related patterns of activity that induce long-term potentiation act as a selection mechanism for the stabilization and localization of spines.
Journal ArticleDOI
β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide
TL;DR: Evidence is presented that the Aβ-mediated inhibition of LTP induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant.
Journal ArticleDOI
Dendritic Spines Lost during Glutamate Receptor Activation Reemerge at Original Sites of Synaptic Contact
TL;DR: Time-lapse fluorescence imaging showed that the vast majority of spines reemerged in the same location from which they disappeared, suggesting that elimination of dendritic spines is not necessarily associated with loss of synaptic contacts.
Journal ArticleDOI
Presynaptic and Postsynaptic Roles of NO, cGK, and RhoA in Long-Lasting Potentiation and Aggregation of Synaptic Proteins
Hong-Gang Wang,Fang Min Lu,Iksung Jin,Hiroshi Udo,Eric R. Kandel,Jan de Vente,Ulrich Walter,Suzanne M. Lohmann,Robert D. Hawkins,Irina Antonova +9 more
TL;DR: This work has investigated whether the increase in puncta involves retrograde signaling through the NO-cGMP- cGK pathway and also examined the possible roles of two classes of molecules that regulate the actin cytoskeleton: Ena/VASP proteins and Rho GTPases.
References
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