Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Selective muscarinic regulation of functional glutamatergic Schaffer collateral synapses in rat CA1 pyramidal neurons.
David Fernández de Sevilla,Carolina Cabezas,Amaranta N. Oshima de Prada,Abel Sanchez-Jimenez,Washington Buño +4 more
TL;DR: The results suggest that SCs have two types of terminals, one in functional synapses, selectively sensitive to regulation through activation of muscarinic receptors, and the other in silent synapses less sensitive to that regulation.
Journal ArticleDOI
Chronic Alcohol Drinking Alters Neuronal Dendritic Spines in the Brain Reward Center Nucleus Accumbens
TL;DR: It is demonstrated for the first time that chronic alcohol exposure causes structural alteration of dendrites and their spines in the key reward brain region in animals that have a genetic background leading to alcohol addiction.
Journal ArticleDOI
Evidence demonstrating role of microRNAs in the etiopathology of major depression.
TL;DR: The possibility that dysregulation of miRNAs and/or altered miRNA response may contribute to the etiology and pathophysiology of depressive disorder is discussed.
Journal ArticleDOI
The Role of Lactate-Mediated Metabolic Coupling between Astrocytes and Neurons in Long-Term Memory Formation.
TL;DR: Some new insights that emerged from recent studies implicating astrocytic glycogen and glucose metabolisms, and particularly their coupling to neuronal functions via lactate, as an essential mechanism for long-term memory formation are considered.
Journal ArticleDOI
Morphological changes in hippocampal dentate gyrus synapses following spatial learning in rats are transient.
TL;DR: Investigation of morphological changes in the hippocampal dentate gyrus of 3‐month‐old male rats at 3, 9 and 24’h after training to find a hidden platform in a Morris water maze indicated that only animals in the 9‐ and 24‐h groups, not the 3‐h group, displayed significant retention of platform location.
References
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The unbiased estimation of number and sizes of arbitrary particles using the disector
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