Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
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Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia
TL;DR: Hosynaptic potentiation produced by tetanic stimulation of the presynaptic neuron in Aplysia is examined and results indicate that rapid recruitment of synaptic components is not limited to hippocampal potentiation and support the hypothesis that activity-dependent types of plasticity involve rapid recruit of presynptic proteins, whereas neuromodulatory types of Plasticity involve more delayed recruitment.
Journal ArticleDOI
Postsynaptic actin filaments at the giant mossy fiber-unipolar brush cell synapse.
TL;DR: It is observed that prominent, but loosely organized, bundles of microfilaments at the subsynaptic region of the MF‐UBC synapse that linked the postsynaptic density with the cytoskeletal core of the dendritic branchlets contain little β‐actin.
Self-repair in the brain : a neural network perspective
TL;DR: It is argued that memory representations in the brain are endowed with a self-repair capacity and a theory of maintenance of redundancy is presented and it is demonstrated how it can extend the lifetime of memory representations.
Journal ArticleDOI
Synaptic mechanisms underlying pheromonal memory in vomeronasal system.
TL;DR: The neural mechanisms underlying learning and memory were determined by employing a convenient model of pheromone-induced olfactory memory (pheromonal memory), which revealed a “self-inhibition” of MT cells activity in response to pheromonal signals of the partner that can disrupt its signals at the AOB thereby preventing the signals from reaching the central brain.
Journal ArticleDOI
Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII
Małgorzata Alicja Śliwińska,Anna Cały,Malgorzata Borczyk,Magdalena Ziółkowska,Edyta Skonieczna,Magdalena Chilimoniuk,Tytus Bernaś,Tytus Bernaś,K. Peter Giese,Kasia Radwanska +9 more
TL;DR: The data support the hypothesis that formation of memory leaves long-lasting footprint on the ultrastructure of brain circuits; however, the form of circuit remodeling changes with age.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
TL;DR: DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation of the temporal program of gene expression accompanying the metabolic shift from fermentation to respiration, and the expression patterns of many previously uncharacterized genes provided clues to their possible functions.
Journal ArticleDOI
A simple method for organotypic cultures of nervous tissue
TL;DR: Hippocampal slices prepared from 2-23-day-old neonates were maintained in culture at the interface between air and a culture medium and yielded thin slices which remain 1-4 cell layers thick and are characterized by a well preserved organotypic organization.
Journal ArticleDOI
The unbiased estimation of number and sizes of arbitrary particles using the disector
TL;DR: A three‐dimensional counting rule and its integral test system, the disector, for obtaining unbiased estimates of the number of arbitrary particles in a specimen is presented.
PatentDOI
Dissecting the regulatory circuitry of a eukaryotic genome
TL;DR: The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.
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