Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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β-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
TL;DR: It is suggested that the cadherin–β-catenin complex is an integral component of synaptic strength regulation and plays a basic role in coupling synapse function and spine morphology.
Journal ArticleDOI
AMPA receptors as drug targets in neurological disease--advantages, caveats, and future outlook
TL;DR: In this article, a review suggests a link between AMPA receptor function and debilitating neuropathologies, and discusses the current state of therapies targeting AMPA receptors in four diseases, including amyotrophic lateral sclerosis, stroke, epilepsy, and Alzheimer's.
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Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications.
TL;DR: The role of microRNAs in major depressive disorder (MDD) is discussed in a comprehensive and critical manner in this article, where the authors consider the role of miRNAs as biomarkers in disease pathogenesis and monitoring therapeutic responses.
Book ChapterDOI
Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia
TL;DR: The insights provided by these studies suggest the synaptic differentiation and growth induced by learning in the mature nervous system are highly dynamic and often rapid processes that can recruit both molecules and mechanisms used for de novo synapse formation during development.
Journal ArticleDOI
Structural and functional plasticity of dendritic spines - root or result of behavior?
TL;DR: It is likely that structural changes in dendritic spines are both instigators and results of behavioral changes, and improved research tools and methods are needed to experimentally and directly manipulate spine dynamics in order to more empirically delineate the relationship between spine structure and behavior.
References
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Related Papers (5)
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
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