Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation?
TL;DR: Using molecular mechanics modeling and electrostatic profiling, it is found that spatial dimensions and geometry of the extended CaMKII kinase domains precisely match those of MT hexagonal lattices, which suggests sets of six Ca MKII kinases domains phosphorylate hexagonal MT lattice neighborhoods collectively, e.g. conveying synaptic information as ordered arrays of six “bits”, and thus “bytes”.
Journal ArticleDOI
Delayed feedback disrupts the procedural-learning system but not the hypothesis-testing system in perceptual category learning.
W. Todd Maddox,A. David Ing +1 more
TL;DR: A strong performance decrement for information-integration but not rule-based category learning under delayed feedback was revealed that was due to an increase in the number of observers using hypothesis-testing strategies to solve the information- integration task, and lower accuracy rates for the few observers using information-Integration strategies.
Journal ArticleDOI
Cadherin activity is required for activity-induced spine remodeling
Ko Okamura,Hidekazu Tanaka,Yoshiki Yagita,Yoshiki Yagita,Yoshinaga Saeki,Akihiko Taguchi,Yasushi Hiraoka,Ling-Hui Zeng,David R. Colman,Naomasa Miki +9 more
TL;DR: It is shown that depolarization induces the enlargement of the width of spine head, and that cadherin activity is essential for this synaptic rearrangement, and suggested that caderin-based adhesion machinery coupled with the actin-cytoskeleton is critical for the remodeling of synaptic apposition zone.
Journal ArticleDOI
Spine changes associated with long-term potentiation.
TL;DR: A view is emerging that suggests that morphologic changes of spine synapses are associated with LTP and that they not only correlate with, but probably also contribute to the increase in synaptic transmission.
Journal ArticleDOI
NMDA-Dependent Proteolysis of Presynaptic Adhesion Molecule L1 in the Hippocampus by Neuropsin
Kazumasa Matsumoto-Miyai,Ayako Ninomiya,Hironobu Yamasaki,Hideki Tamura,Yukiko Nakamura,Sadao Shiosaka +5 more
TL;DR: It is shown that a serine protease, neuropsin, directly and specifically modifies the synaptic adhesion molecule L1, which was localized to the presynaptic site of the asymmetric synapse in the mouse hippocampus, which is involved in NMDA receptor-dependent synaptic plasticity.
References
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