Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high-frequency stimulation alone.
Tiruchinapalli M. Dhanrajan,Marina A. Lynch,Áine M. Kelly,Victor I. Popov,Victor I. Popov,Dmitri A. Rusakov,Dmitri A. Rusakov,Michael G. Stewart +7 more
TL;DR: A high‐frequency stimulation protocol in vivo to induce long‐term potentiation (LTP) in the hippocampal dentate gyrus of aged (22‐month‐old) rats is used and a clear distinction between animals that sustain LTP and those that fail to sustain it is found.
Journal ArticleDOI
Neuronal nitric oxide synthase and NADPH oxidase interact to affect cognitive, affective, and social behaviors in mice
TL;DR: Evidence is provided that the NOX and nNOS redox signaling cascades interact in the brain to affect both cognitive function and social behavior.
Journal ArticleDOI
Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons.
TL;DR: It is demonstrated that Y1‐R is a presynaptic receptor in NPY‐ or catecholamine‐containing axon terminals within the mNTS as well as a postsynaptic receptor on NPy‐ orcatecholamines‐containing neurons that are contacted by axon Terminals that likely contain excitatory amino acid transmitters.
Journal ArticleDOI
CREB phosphorylation coincides with transient synapse formation in the rat hippocampal dentate gyrus following avoidance learning.
TL;DR: The view that CREB-mediated gene transcription is a requirement for long-term memory consolidation and may be directly implicated in the process of synaptic growth is supported.
Journal ArticleDOI
Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons.
Guillaume Rami,Olivier Caillard,Igor Medina,Christophe Pellegrino,Abdellatif Fattoum,Yezekiel Ben-Ari,Lotfi Ferhat +6 more
TL;DR: Findings show that acidic calponin regulates dendritic spine morphology and density, likely via regulation of the actin cytoskeleton reorganization and dynamic.
References
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