Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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The Regulation of Dendritic Spine Plasticity by EphB and N-methyl-D-aspartate Receptors Through Spatial Control Over Cofilin Activity in Mature Hippocampal Neurons
TL;DR: Novel functions of b- Arrestin1 in the development of mature dendritic spines, and b-Arrestin2 in NMDAR-mediated dendrite spine plasticity through spatial control over cofilin activity are demonstrated.
DissertationDOI
Structural plasticity of synaptic connectivity in the adult central nervous system
TL;DR: It is found that hippocampal mossy fibers exhibit structural plasticity at the level of the large mossy fiber terminals (LMTs) and that this remodeling respond to experience and age, and is regulated by spiking activity and mGluR2-sensitive transmitter release from LMTs and can define subtypes of hippocampal granule cells that seem to belong to distinct microcircuits.
Book ChapterDOI
Constitutive Inference and the Problem of a Complete Variation of Factors
TL;DR: This paper aims to solve a potential problem for the methodology of constitutive inference offered by Harbecke by arguing that the proposed solution accommodates well all schematic situations in which the impossibility of varying all test factors could be expected to lead to false inferences.
Presynaptic Substrates Mediating Fos- and Jun-dependent Plasticity at the Drosophila Neuromuscular Junction
TL;DR: Electrophysiological and FM1-43 based measurements demonstrate that enhanced neurotransmitter release is accompanied by an increase in the actively cycling synaptic-vesicle pool at the expense of the reserve pool, and suggest transcriptional mechanisms believed to participate in sustained reserve pool mobilization may underlie this form of plasticity.
References
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Related Papers (5)
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
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