Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Ethanol and brain plasticity: receptors and molecular networks of the postsynaptic density as targets of ethanol.
TL;DR: This review will focus on the cellular and molecular neuroscience of alcoholism, with emphasis on events at the glutamatergic postsynaptic density (PSD) and dendritic spine dynamics that appear to underlie much of the structural and functional plasticity of the CNS.
Journal ArticleDOI
Age-dependence in the homeostatic upregulation of hippocampal dendritic spine number during blocked synaptic transmission.
TL;DR: Age-dependent changes in the manifestation of homeostatic control of dendritic spines that could be mediated by maturational changes in mechanisms regulating postsynaptic calcium are revealed.
Journal ArticleDOI
Dendritic spine plasticity: looking beyond development.
Kimberly J. Harms,Anna Dunaevsky +1 more
TL;DR: The formation and modification of excitatory synapses on dendritic spines as it relates to plasticity in the central nervous system after the initial phase of synaptogenesis is reviewed.
Journal ArticleDOI
Principles of glutamatergic synapse formation: seeing the forest for the trees.
Noam E. Ziv,Craig C. Garner +1 more
TL;DR: General principles regarding glutamatergic synapse formation in the central nervous system are beginning to emerge and concern the specific roles that dendrites and axons play in the induction of synaptic differentiation.
Journal ArticleDOI
Structural plasticity: mechanisms and contribution to developmental psychiatric disorders
TL;DR: The hypothesis that alterations of structural plasticity could represent a common mechanism contributing to the cognitive and functional defects observed in diseases such as intellectual disability, autism spectrum disorders and schizophrenia is discussed.
References
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