Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Heparin-binding growth-associated molecule (HB-GAM) in activity-dependent neuronal plasticity in hippocampus
TL;DR: The two thrombospondin type I repeat domains of heparin-binding growth-associated molecule are necessary and sufficient for the interaction with hippocampal neurons.
Dissertation
Impact de la protéine CHMP2B et de ses variants pathogènes sur le modelage des membranes biologiques
TL;DR: In this paper, a travail a consiste a preciser les mecanismes moleculaires d'action of CHMP2B afin de mieux cerner les causes potentielles des ces dysfonctionnements.
Dissertation
Effects of stress on CA3 pyramidal neurons in the pregnant female rat
TL;DR: Tese de mestrado. Biologia Humana e Ambiente, Faculdade de Ciencias, Lisbon, Portugal, 2010,.
Neuroplasticity following skill and strength training : evidence from transcranial magnetic stimulation studies
Alan J. Pearce,Dawson Kidgell +1 more
Journal ArticleDOI
Deficiency in FTSJ1 Affects Neuronal Plasticity in the Hippocampal Formation of Mice
Viola von Bohlen und Halbach,Simone Venz,Simon Nwakor,Christian Hentschker,Elke Hammer,Heike Junker,Andreas W. Kuss,Oliver von Bohlen und Halbach,Lars Riff Jensen +8 more
TL;DR: FTSJ1 has an impact on neuronal plasticity in the murine hippocampal area CA1 at the morphological and physiological levels, which, in conjunction with comparable changes in other cortical areas, might accumulate in disturbed learning and memory functions.
References
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A simple method for organotypic cultures of nervous tissue
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Journal ArticleDOI
The unbiased estimation of number and sizes of arbitrary particles using the disector
TL;DR: A three‐dimensional counting rule and its integral test system, the disector, for obtaining unbiased estimates of the number of arbitrary particles in a specimen is presented.
PatentDOI
Dissecting the regulatory circuitry of a eukaryotic genome
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