Journal ArticleDOI
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TLDR
In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.Abstract:
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines Three-dimensional reconstruction revealed that these spines arose from the same dendrite As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapsesread more
Citations
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Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
TL;DR: How the molecular aspects of glutamate malfunction can explain some of the neuropathology observed in schizophrenia, and how the available treatment intervenes through the glutamate system is discussed.
Journal ArticleDOI
Motor enrichment and the induction of plasticity before or after brain injury.
TL;DR: It is possible that, in the chronic stages after brain injury, a regimen of exercise would reactivate mechanisms of plasticity and thus enhance rehabilitation targeting residual functional deficits.
Journal ArticleDOI
Visualization of changes in presynaptic function during long-term synaptic plasticity.
TL;DR: Enhanced presynaptic function during long-term potentiation (LTP) induced either chemically (with tetraethylammonium), or by high-frequency (200-Hz) electrical stimulation implied that a long-lasting increase in the efficacy of synaptic transmission is likely to depend, at least in part, on enhanced transmitter release from the Presynaptic neuron.
Journal ArticleDOI
Depolarization Drives β-Catenin into Neuronal Spines Promoting Changes in Synaptic Structure and Function
TL;DR: It is demonstrated that β-catenin, which mediates interactions between cadherins and the actin cytoskeleton, moves from dendritic shafts into spines upon depolarization, increasing its association with cadherin.
Journal ArticleDOI
Regulation of hippocampal synaptic plasticity by cyclic amp-dependent protein kinases
Peter V. Nguyen,N.H Woo +1 more
TL;DR: The roles of PKA in activity-dependent forms of hippocampal synaptic plasticity are reviewed by highlighting particular themes that have emerged in ongoing research, and many of the substrates that have been implicated as targets for PKA's actions, including CREB, protein phosphatases, and glutamatergic receptors are discussed.
References
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The unbiased estimation of number and sizes of arbitrary particles using the disector
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