Journal ArticleDOI
MicroRNAs and Malaria - A Dynamic Interaction Still Incompletely Understood.
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TLDR
The role of microRNA in the pathogenesis of severe malaria remains incompletely understood, hindering our ability to treat this disease as discussed by the authors, and the role of small, non-coding RNAs play in the progression, pathogenesis, and resistance to, malaria.Abstract:
Malaria is a mosquito-borne infectious disease caused by parasitic protozoa of the genus Plasmodium. It remains a major problem affecting humans today, especially children. However, the pathogenesis of malaria, especially severe malaria, remains incompletely understood, hindering our ability to treat this disease. Of recent interest is the role that small, non-coding RNAs play in the progression, pathogenesis of, and resistance to, malaria. Independent studies have now revealed the presence of microRNA (miRNA) in the malaria parasite, vector, and host, though these studies are relatively few. Here, we review these studies, focusing on the roles specific miRNA have in the disease, and how they may be harnessed for therapeutic purposes.read more
Citations
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Journal ArticleDOI
MicroRNA profiling of the intestinal tissue of Kazakh sheep after experimental Echinococcus granulosus infection, using a high-throughput approach
TL;DR: To identify microRNA controlling resistance to CE in the early stage of infection, microRNA profiling was conducted in the intestinal tissue of sheep with resistant and non-resistant MHC haplotypes after peroral infection with E. granulosus.
Journal ArticleDOI
Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-β signalling pathways.
Aarón Martin-Alonso,Amy Cohen,María Antonieta Quispe-Ricalde,Pilar Foronda,Agustín Benito,Pedro Berzosa,Basilio Valladares,Georges E. Grau +7 more
TL;DR: The data implies that, at least in the mouse model, miRNA may play a regulatory role in CM pathogenesis, and suggests that these miRNA, through their regulation of downstream targets, may be vitally involved in the neurological syndrome.
Journal ArticleDOI
Routine In Vitro Culture of Plasmodium falciparum: Experimental Consequences?
Sandra Duffy,Vicky M. Avery +1 more
TL;DR: It is reasoned that culture conditions should be re-established as a primary consideration in in vitro malaria experimentation.
Journal ArticleDOI
Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria
TL;DR: The change in abundance of miRNA was studied following infection of CBA mice with Plasmodium berghei ANKA strain, and Plas modium yoelii, which causes severe malaria without cerebral complications, termed non-CM, suggesting that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.
Journal ArticleDOI
Screening and identification of potential novel biomarker for diagnosis of complicated Plasmodium vivax malaria.
TL;DR: In silico analysis of the common targets of up-regulated miRNAs revealed UBA52 and hsa-miR-7977 as majorly regulated hubs in the PPI and mRNA–miRNA networks, suggesting their putative role in complicated P. vivax malaria.
References
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Journal ArticleDOI
The lack of suppressor of cytokine signalling‐1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA
Denise V. R. Bullen,Diana S. Hansen,Mary-Anne Siomos,Louis Schofield,Warren S. Alexander,Emanuela Handman +5 more
TL;DR: Mice lacking SOCS1 exhibited decreased splenic cellularity and a reduced ratio of CD4 : CD8 lymphocytes, which were maintained during infection, however, the ratio of IFN‐γ to IL‐4 mRNA expression during infection was similar in SOCS 1 –/– and control mice suggesting that a dramatic shift in the ratios of Th1 : Th2 responses does not account for the resistance to disease.
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