MicroRNAs and Malaria - A Dynamic Interaction Still Incompletely Understood.

TLDR: The role of microRNA in the pathogenesis of severe malaria remains incompletely understood, hindering our ability to treat this disease as discussed by the authors, and the role of small, non-coding RNAs play in the progression, pathogenesis, and resistance to, malaria.

Abstract: Malaria is a mosquito-borne infectious disease caused by parasitic protozoa of the genus Plasmodium. It remains a major problem affecting humans today, especially children. However, the pathogenesis of malaria, especially severe malaria, remains incompletely understood, hindering our ability to treat this disease. Of recent interest is the role that small, non-coding RNAs play in the progression, pathogenesis of, and resistance to, malaria. Independent studies have now revealed the presence of microRNA (miRNA) in the malaria parasite, vector, and host, though these studies are relatively few. Here, we review these studies, focusing on the roles specific miRNA have in the disease, and how they may be harnessed for therapeutic purposes.