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Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures
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TLDR
In this article, self-assembly is defined as the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds.Abstract:
Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.read more
Citations
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Journal ArticleDOI
Folding DNA to create nanoscale shapes and patterns
TL;DR: This work describes a simple method for folding long, single-stranded DNA molecules into arbitrary two-dimensional shapes, which can be programmed to bear complex patterns such as words and images on their surfaces.
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Fabrication of novel biomaterials through molecular self-assembly.
TL;DR: Two complementary strategies can be used in the fabrication of molecular biomaterials as discussed by the authors : chemical complementarity and structural compatibility, both of which confer the weak and noncovalent interactions that bind building blocks together during self-assembly.
Journal ArticleDOI
Design and self-assembly of two-dimensional DNA crystals
TL;DR: The design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules that create specific periodic patterns on the nanometre scale are reported.
Journal ArticleDOI
Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science
TL;DR: This review is focused on current approaches emerging at the intersection of materials research, nanosciences, and molecular biotechnology, which is closely associated with both the physical and chemical properties of organic and inorganic nanoparticles.
Journal ArticleDOI
Self-assembly of DNA into nanoscale three-dimensional shapes
Shawn M. Douglas,Hendrik Dietz,Tim Liedl,Björn Högberg,Franziska Graf,Franziska Graf,William M. Shih,William M. Shih +7 more
TL;DR: This work demonstrates the design and assembly of nanostructures approximating six shapes—monolith, square nut, railed bridge, genie bottle, stacked cross, slotted cross, and heterotrimeric wireframe icosahedra with precisely controlled dimensions.
References
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DNA Minicircles with Gaps for Versatile Functionalization
Goran Rasched,Damian Ackermann,Thorsten Schmidt,Peter Broekmann,Alexander Heckel,Michael Famulok +5 more
TL;DR: The key step in the preparation of DNA minicircles with sequence-specific functionalization focuses on a preformed incomplete minicircle MCgap containing a 21-nucleotide single-stranded gap region at a defined position, thereby allowing, for example, their guided modification with functional groups through hybridization with synthetic oligonucleotides.
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On Controllability and Applicability of Surface Molecular Self-Assemblies.
TL;DR: Recent achievements of MSAs on single crystal metal surfaces are overviewed with a focus on their controllability and applicability in tweaking the properties of the molecular building blocks involved.
Book ChapterDOI
Self-Assembly and Self-Assembled Monolayers in Micro- and Nanofabrication
TL;DR: Despite the extraordinary success of current techniques for microfabrication, new techniques are needed as mentioned in this paper for large scale, high volume processing, and other considerations such as capital and processing costs, waste management, environmental concerns, and the degree of perfection of the final structures may also force the development of new methods for micro fabrication.
Journal ArticleDOI
Supramolecular double-stranded Archimedean spirals and concentric toroids.
Norihiko Sasaki,Norihiko Sasaki,Mathijs F. J. Mabesoone,Jun Kikkawa,Tomoya Fukui,Nobutaka Shioya,Takafumi Shimoaka,Takeshi Hasegawa,Hideaki Takagi,Rie Haruki,Nobutaka Shimizu,Shin-ichi Adachi,E. W. Meijer,Masayuki Takeuchi,Kazunori Sugiyasu,Kazunori Sugiyasu +15 more
TL;DR: Different self-assembly patterns in a porphyrin structure which can form – depending on the concentration - spirals or toroids are reported, illustrating the richness of self-assembled structures at higher levels of hierarchy and demonstrating a topological effect in noncovalent synthesis.
Journal ArticleDOI
Controlled drug delivery with nanoassemblies of redox-responsive prodrug and polyprodrug amphiphiles.
Zhengyu Deng,Shiyong Liu +1 more
TL;DR: This review highlights recent progresses on emerging applications of redox-activatable nanostructures self-assembled from prodrug and polyprodrug amphiphiles, thus considerably reducing the occurrence of systemic toxicities.