Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Tableting process-induced solid-state polymorphic transition
Journal ArticleDOI
Effects of Different Formulation Methods on Drug Crystallinity, Drug-Carrier Interaction, and Ex Vivo Permeation of a Ternary Solid Dispersion Containing Nisoldipine
May Kyaw Oo,Syed Mahmood,Wong Tin Wui,Uttam Kumar Mandal,Bappaditya Chatterjee,Bappaditya Chatterjee +5 more
TL;DR: In this article, the effect of preparation method on drug crystallinity, drug-polymer interaction, ex vivo permeability, and solid dispersion stability was evaluated using X-ray diffraction and infrared-red spectroscopy.
Journal ArticleDOI
Crystal forms of a new 5-HT4 receptor agonist DA-6886
Su-Ryun Tak,Young-Taek Sohn +1 more
TL;DR: In this article, the existence of polymorphs and pseudopolymorphs of DA-6886 was investigated by recrystallization and characterized by differential scanning calorimetry, thermogravimetric (TG) analysis, and powder X-ray diffractometry (PXRD).
Journal ArticleDOI
Thermal behaviour of melt crystallized phenylbutazone
TL;DR: In this paper, it was suggested that the value of the area ratio is related to the energy supplied to the melt phenylbutazone in the first heat cycle, and that the energy level that the melt should reach to crystallize as the metastable Form C should be higher than the essential one to crystallise as the stable Form A.
Journal ArticleDOI
Thermal and pharmacological characterization of some new bis-xanthine derivatives
TL;DR: In this paper, the 8-substituted bis-xanthine derivatives with various substituents have been synthesized taking in the view the previous results with xanthine derivative, exhibiting enhanced and multiplied pharmacological properties in respect with those of theophylline.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.