Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Solid Forms of Amlodipine Besylate: Physicochemical, Structural, and Thermodynamic Characterization
Vishal Koradia,Heidi Lopez de Diego,Karla Frydenvang,Michiel Ringkjøbing-Elema,Anette Müllertz,Andrew D. Bond,Jukka Rantanen +6 more
TL;DR: Amlodipine besylate, a calcium channel antagonist widely used in the treatment of hypertension and coronary artery disease, has been found to exist in four solid forms: anhydrate, monohydrate, dihydrate and amorphous as mentioned in this paper.
Journal ArticleDOI
Inconvenient Truths about Solid Form Landscapes Revealed in the Polymorphs and Hydrates of Gandotinib
Doris E. Braun,Jennifer A. McMahon,Rajni M. Bhardwaj,Jonas Nyman,Jonas Nyman,Marcus A. Neumann,Jacco van de Streek,Susan M. Reutzel-Edens +7 more
TL;DR: In this article, the crystal structural relationships underpinning the dehydration-rehydration pathways of gandotinib were elucidated as a function of temperature and humidity, which required not only temperature but also humidity.
Patent
5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
TL;DR: A hydrate of 5-[4]-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, characterised in that it: (i) comprises water in the range of from 0.4 to 2.5 % w/w; and (ii) provides an infra red spectrum containing peaks at 1749, 1703, 1645, 1623, 1365 and 736 cm −1 ; and/or (iii) provides
Patent
Method for producing 1,2-dihydropyridine-2-one compound
Akio Kayano,Katsutoshi Nishiura +1 more
TL;DR: In this article, a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III) with high yield and high purity was described.
Patent
Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
TL;DR: In this article, the present invention provides a novel hydrate of 5-[4]-2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.