Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Patent
Cyclopropyl amide derivatives
James Arnold,Phil Edwards,Andrew Griffin,Thierry Groblewski,Denis Labrecque,Scott Throner,Steven Wesolowski,Todd Andrew Brugel,Dean G. Brown +8 more
TL;DR: In this article, at least one cyclopropyl amide derivative of formula (I) was used for treating histamine H3 receptor associated condition therewith, as well as a pharmaceutical composition comprising at least 1 cycloprocessyl amides derivative (I).
Journal ArticleDOI
Solid state of CG-400549, a novel FabI inhibitor: characterization, dissolution, transformation.
Bo-Yeon Kim,Young-Taek Sohn +1 more
TL;DR: The polymorphic and pseudopolymorphic forms of CG-400549, a novel FabI inhibitor with potent in vivo activity were prepared and characterized by differential scanning calorimetry, powder X-ray diffractometry and thermogravimetric analysis and they showed significant differences in the dissolution rate.
Journal ArticleDOI
Effect of Recrystallization on the Pharmaceutical Properties of Valsartan for Improved Therapeutic Efficacy
TL;DR: In this article, an attempt has been made to improve the aqueous solubility of Valsartan by recrystallization of the drug from a variety of different organic solvents.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.