Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Journal ArticleDOI
Polymorphism in Multiple Component Crystals: Forms III and IV of Gallic Acid Monohydrate
TL;DR: Gallic acid monohydrate is the first tetramorphic hydrate for which fractional coordinates have been determined, and analysis of the hydrogen bonding patterns in these and other polymorphic hydrates suggests that waters of hydration are a nemesis to crystal engineers as mentioned in this paper.
Patent
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
TL;DR: In this paper, a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2yl)benzoic acid in substantially free form was described.
Journal ArticleDOI
Exploration of the Pyrazinamide Polymorphism at High Pressure
Xiao Tan,Kai Wang,Shourui Li,Hongsheng Yuan,Tingting Yan,Jing Liu,Ke Yang,Bingbing Liu,Guangtian Zou,Bo Zou +9 more
TL;DR: It is proposed that the stabilities of the α and δ forms upon compression are due to the special dimer connection that these forms possess, and that the γ phase undergoes phase transition to the β phase at a pressure of about 4 GPa.
Journal ArticleDOI
Use of In Situ Atomic Force Microscopy to Follow Phase Changes at Crystal Surfaces in Real Time
Ranjit Thakuria,Mark D. Eddleston,Ernest H. H. Chow,Gareth O. Lloyd,Barry John Aldous,Joseph F. Krzyzaniak,Andrew D. Bond,William Jones +7 more
TL;DR: The conversion of a metastable polymorph of the caffeine-glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent-contact-mode atomic force microscopy.
Journal ArticleDOI
Molecular Conformations of the Polymorphic Forms of Cimetidine from 13C Solid-State NMR Distance and Angle Measurements
TL;DR: In this paper, the structures of four crystalline forms of double 13C-labeled cimetidine, three anhydrates (A, B, and C) and a monohydrate (M1), were examined using 13C cross polarization magic angle spinning (CP-MAS) NMR methods.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.