Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Patent
Polymorphs of 3-(e)-2-{2-[6-(2-cyanophenoxy) pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate
Sharona Zamir,Inna Faktorovitch +1 more
TL;DR: In this article, the authors proposed a method for the synthesis of polymorphic and amorphous forms of azoxystrobin for combating fungi on agricultural and horticultural crops and up-land.
Journal ArticleDOI
Detecting Crystalline Nonequilibrium Phases on the Nanometer Scale
TL;DR: In this paper, the use of automated electron diffraction tomography (ADT) is presented as a novel approach for crystallization studies at the nanometer scale for nonequilibrium phases.
Journal ArticleDOI
Structural studies of five novel bile acid-4-aminopyridine conjugates.
Kari Ahonen,Manu Lahtinen,Miika Löfman,Anniina Kiesilä,Arto Valkonen,Elina Sievänen,Nonappa,Erkki Kolehmainen +7 more
TL;DR: Systematic crystallization experiments revealed a number of structural modifications and/or solvate/hydrate systems for these conjugates, particularly, cholic acid conjugate exhibited five distinct structure modifications, including one anhydrous form, mono- and dihydrates, as well as ethanol and 2-butanol solvates.
Patent
Method for treating hypertonia with N-(2-furfuryl)-4-chloro-5-sulfamoyl-anthranilic acid and preparations thereof
TL;DR: A method for treating hypertonia with a preparation of N-(2-furfuryl)-4-chloro-5-sulfamoyl-anthranilic acid having a slightly retarded release is described in this article.
Journal ArticleDOI
Hygroscopicity of Celiprolol Hydrochloride Polymorphs
TL;DR: In this paper, the moisture absorption of two crystalline forms (form I and form II) of celiprolol hydrochloride was investigated at different relative humidity levels, and it was found that the high melting form I undergoes a transition to a low melting form II at high relative humidity.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.