Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Polymorphism, isostructurality and physicochemical properties of glibenclamide salts
TL;DR: In this article, aqueous solubility and hydration stability study of GBA-sodium, GBA ammonium, and glibenclamide-potassium (GBA-K) is reported.
Journal ArticleDOI
Preparation and Characterization of Polymorphs for an LTD4 Antagonist, RG 12525
TL;DR: This report describes the preparation and characterization of two polymorphic forms of RG 12525, a leukotriene D4 (LTD4) antagonist, with pure form I melting at 154 degrees C, 3 deg less than the melting temperature of form II.
Journal ArticleDOI
Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs
TL;DR: In this paper, the variability of polymorphs of agomelatine was investigated and the in-vitro invivo correlation were established, and the presence of three polymorphs was corroborated through studies by XRPD, TGA and DSC.
Journal ArticleDOI
Solid-State NMR, X-ray Diffraction, and Thermoanalytical Studies Towards the Identification, Isolation, and Structural Characterization of Polymorphs in Natural Bile Acids
TL;DR: Combined solid-state NMR, powder, and single crystal X-ray diffraction, as well as thermoanalytical studies were performed towards the identification, isolation, and structural characterization of...
Patent
Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof
Marinus Jacobus Verwijs,Rossitza G. Alargova,Ritu Rohit Kaushik,Irina Nikolaevna Kadiyala,Christopher R. Young +4 more
TL;DR: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.