Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Crystallisation in printed droplets: understanding crystallisation of D-mannitol polymorphs
TL;DR: In this paper, the effects of droplet size and the presence of a foreign surface were investigated in comparison to the commonly used manufacturing technique of spray drying, and a dependence of the crystallisation of mannitol polymorphs on either the presence or absence of a surface to favour either the stable or the metastable polymorphs was found.
OtherDOI
Physicochemical Characterization and Principles of Oral Dosage Form Selection
TL;DR: The end result of considering physicochemical properties is to reduce the risk of failure by facilitating the identification of appropriate dosage form design options and, at the same time, allow discovery chemists to maximize chances of identifying commercially viable leads.
Journal ArticleDOI
Polymorphic forms of bisoprolol fumarate
TL;DR: In this paper, two anhydrous forms (Form I and Form II) and a hydrate of bisoprolol fumarate were studied by various solid-state analytical methods: Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRPD), dynamic vapor sorption (DVS) and thermoanalytical methods (thermogravimetry and differential scanning calorimetry).
Journal ArticleDOI
Insights into phase stability of anhydrous/hydrate systems: a Raman‐based methodology
TL;DR: In this paper, the authors present a methodology that allows successful quantitative evaluation of the solid-state hydration and dehydration processes, using FT-Raman spectroscopy, for the caffeine system, a particularly challenging system presenting limited spectral differences between pseudopolymorphs.
Journal ArticleDOI
Polymorphism of chloroquine diphosphate
Anne-Kristin Bjerga Bjåen,Karin Nord,Sigrid Furuseth,Tove Ågren,Hanne Hjorth Tønnesen,Jan Karlsen +5 more
TL;DR: In this article, the transition of anhydrous chloroquine diphosphate into hydrated compounds is possible by storing the drug at high relative humidity and compressive compression of the raw material did result in the formation of a new polymorph.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.