Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Application of Vibrational Spectroscopy to Study Solid-state Transformations of Pharmaceuticals.
TL;DR: Infrared, NIR and Raman spectroscopies are important tools for studying transformations between different crystalline forms, between the crystalline and amorphous form, between hydrate and anhydrous form and for investigating solid-state cocrystal formation.
Studies on a Cholesterol-Lowering Microcrystalline Phytosterol suspension in Oil
TL;DR: In this article, a cholesterol-lowering micro-crystalline phytosterol suspension in oil was used to reduce serum cholesterol levels in the small intestine of mice using a dynamic in vitro study.
Journal ArticleDOI
Crystal structure of nedocromil sodium heptahemihydrate and its comparison with that of nedocromil sodium trihydrate
TL;DR: The crystal structure of one of the hydrated forms of nedocromil sodium, the heptahemihydrate, has been determined by Freer, A. A., Payling, D. W., and Suschitzky, J. L..
Journal ArticleDOI
Studies on mechanism of thermal crystal transformation of sitafloxacin hydrates through melting and recrystallization, yielding different anhydrates depending on initial crystalline forms
TL;DR: The polymorphic and pseudopolymorphic forms of sitafloxacin, a novel fluoroquinolone antibiotic, were characterized by infrared spectroscopy, X-ray diffractometry, and thermal analysis.
Journal ArticleDOI
Heterogeneous nucleation of polymorphs on polymer surfaces: polymer-molecule interactions using a heterogeneous dielectric solvation model.
TL;DR: For the nucleation process in solution where acetaminophen and the polymer surface are surrounded by a solvent, the heterogeneous dielectric solvation model predicts that a sideways orientation is the most stable orientation.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.