Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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New Crystalline Solvates of Atorvastatin Calcium
Yong Suk Jin,Joachim Ulrich +1 more
TL;DR: In this paper, two new crystalline solvates were discovered from amorphous Atorvastatin calcium (ATC) and the analytical results were distinct from those of the previously reported crystalline polymorphs, solvate and amorphized forms.
Journal ArticleDOI
Pseudopolymorphic transitions of niclosamide monitored by Raman spectroscopy
TL;DR: In this article, the kinetics of pseudopolymorphic transitions of niclosamide crystals are characterized using FT-Raman spectroscopy, and both hydration and dehydration were found to be single-step processes, with a half-life time of ca. 142 and 63 h at 24 °C.
Journal ArticleDOI
Investigation of solid-state reactions using variable temperature X-ray powder diffractometry. II. Aminophylline monohydrate.
TL;DR: Variable temperature XRD is a powerful tool to probe reaction kinetics in crystalline pharmaceuticals since it permits simultaneous quantification of multiple solid phases.
Journal ArticleDOI
A novel standard sample powder preparation method for quantitative analysis of polymorphs.
Takehiro Okumura,Makoto Otsuka +1 more
TL;DR: The purpose of this study was to improve the sensitivity and accuracy of the quantitative analysis of polymorphic mixtures by using standard mixture preparation techniques whereby samples at scales of several grams are homogeneously and accurately prepared without decrease in crystallinity.
Journal ArticleDOI
Solid-state characterization of two polymorphic forms of R-albuterol sulfate.
TL;DR: Substantial differences were observed between the solid-state properties of the crystals, confirming the existence of at least two polymorphic forms for R-albuterol sulfate: Form I and Form II.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.