Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
More filters
Reference EntryDOI
Solid‐state Nuclear Magnetic Resonance of Polymorphic Materials
TL;DR: Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is a powerful analytical technique for the analysis of polymorphs, which are molecules that exist in different crystalline phases as mentioned in this paper.
Patent
Compositions and methods for cancer treatment
TL;DR: In this paper, the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer were described. But the present invention relates to the composition of the Stem Cell Inhibitor.
Book ChapterDOI
5.21 – Solid-State Physicochemistry
TL;DR: In this article, the authors summarized the thermodynamic rules which are the driving force of polymorphism, pseudo-polymorphism and apomorphism and the solid state parameters affected by these phenomena e.g. solubility, dissolution rate, hygroscopicity, chemical stability and effect of aging due to kinetic factors.
Patent
Processes for 4-((1R,35)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine or a salt thereof
Lopez De Diego Heidi,Nielsen Ole,Lone Munch Ringgard,Henrik Svane,Allan Carsten Dahl,Mark Howells,Benny Bang-Andersen,Lars Ole Lyngsø,Sherry Lynn Collier +8 more
TL;DR: Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described in this paper.
References
More filters
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.