Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Quantitative plane-resolved crystal growth and dissolution kinetics by coupling in situ optical microscopy and diffusion models : the case of salicylic acid in aqueous solution
TL;DR: In this paper, the growth and dissolution kinetics of salicylic acid crystals are investigated in situ by focusing on individual microscale crystals from a combination of optical microscopy and finite element method (FEM) modeling.
Journal ArticleDOI
Polymorphism of disopyramide.
S R Gunning,M Freeman,J A Stead +2 more
TL;DR: Two crystal forms of disopyramide have been characterized using X‐ray diffraction, differential scanning calorimetry and infrared spectroscopy and the kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout‐Tompkins theory.
Journal ArticleDOI
Some factors influencing dissolution from salicylic acid‐urea solid dispersions
J H Collett,B L Flood,F R Sale +2 more
TL;DR: Evidence was found of compound formation between the constituents of salicylic acid‐urea using a fusion method and an X‐ray diffraction technique, and dissolution rates of drug from non‐disintegrating discs of solid dispersion systems were measured.
Journal ArticleDOI
3′-azido-3′-deoxy-5′-o-isonicotinoylthymidine, a new prodrug of zidovudine. synthesis, solid state characterization and anti hiv-1 activity
Marisa I. Motura,Guillermo N. Moroni,Silvina A. Teijeiro,Horacio Salomón,Margarita C. Briñón +4 more
TL;DR: The novel nucleoside exhibited antiviral activity against standard and resistant strain panels of HIV-1 as well as cytotoxicity similar to that of AZT.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.