Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Journal Article
Influence of solid-state chemistry in drug substances in pharmaceutical products. A review
TL;DR: In this paper, the authors present a number of routes such as co-crystallization, polymorphism and salt formation to improve physico-chemical properties of drugs, which can be implemented through an in detail knowledge of crystallization processes and the molecular properties.
Patent
Malonate salt of 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and uses of same
Lopez De Diego Heidi,Nielsen Ole,Lone Munch Ringgard,Henrik Svane,Allan Carsten Dahl,Mark Howells,Benny Bang-Andersen,Lars Ole Lyngsø +7 more
TL;DR: In this article, the use of hydrogen malonate salt for the treatment of schizophrenia and other psychotic disorders is described. But the authors did not specify the uses of the same for other disorders.
Patent
Forme cristalline du sel de sodium de 5-amino-2,3-dihydrophtalazine-1,4-dione, préparations pharmaceutiques la contenant et procédés pour sa production
Thomas J. Martin,Josef Breu,Wolfgang Brysch,David Kosel,Beate Ludescher,Michael Niedermaier,Jörg Von Wegerer +6 more
TL;DR: In this paper, a nouvelle forme cristalline du sel de sodium de 5-amino-2,3-dihydrophtalazine-1,4-dione was presented.
Patent
Polymorphs and amorphous forms of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
TL;DR: In this article, the authors present methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.