Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Solid-State Nuclear Magnetic Resonance Spectroscopy-Pharmaceutical Applications
TL;DR: This review focuses on the use of solid-state NMR techniques for the characterization of pharmaceutical solids (drug substance and dosage form) through methods for studying structure and conformation, analyzing molecular motions, and measuring internuclear distances.
Journal ArticleDOI
Characterization of the solid state: quantitative issues
TL;DR: Many of the common techniques that are used for quantitative phase analysis and many of the considerations that are necessary for the development of such methods are described.
Journal ArticleDOI
Physicochemical properties and x-ray structural studies of the trigonal polymorph of carbamazepine
TL;DR: The trigonal polymorph of carbamazepine (alpha-carbamazepines) was obtained by crystallization from a number of solvents by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray power diffraction, thermal microscopy, and powder and intrinsic dissolution rates.
Journal ArticleDOI
Muster aus H‐Brücken: ihre Funktionalität und ihre graphentheoretische Analyse in Kristallen
TL;DR: Wechselwirkungen zwischen Molekulen werden durch intermolekulare Krafte bestimmt, deren energetische and geometrische Eigenschaften viel weniger gut verstanden sind als die von klassischen chemischen Bindungen.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.