Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Patent
Polymorph forms of n-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
Haruko Yamabe,Takayuki Ishige +1 more
TL;DR: In this paper, a polymorph crystal form A and B of N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2, 3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide are used for activating a malfunctioned cholinergic neuron that is associated with memory loss disturbances.
Dissertation
Spectroscopic investigation and quantitation of polymorphism and crystallinity of pharmaceutical compounds
TL;DR: In this paper, Fourier transform Raman spectroscopy, terahertz pulsed Spectroscopy and second harmonic generation were used to characterise and quantify polymorphism and crystallinity of pharmaceutical compounds.
Journal ArticleDOI
Effect of pulverization on dehydration behavior of crystals of GK-128, a serotonin3 receptor antagonist
TL;DR: The results of comparison of powder X-ray diffraction patterns of pulverized GK-128 and intact GK, a newly developed serotonin3 receptor antagonist, suggested that water molecules could be removed easily along the c-axis of Gk-128 crystals.
Book ChapterDOI
Intermolecular Methyl Migration in the Solid State
TL;DR: In this article, the basic rules for solid-state photochemistry in the crystal were formulated by using the term "topochemical" which was coined by Hertel [2] and they were classified as non-topochemically controlled reactions.
Reference EntryDOI
Role of Preformulation in Development of Solid Dosage Forms
TL;DR: Preformulation testing for oral solid dosage forms in a drug discovery setting and the main objective of filing an abbreviated new drug application (ANDA) is focused on.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.