Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Solid-state of pharmaceutical compounds
D. Giron,M. Mutz,S. Garnier +2 more
TL;DR: In this paper, the authors summarized the different steps needed for a proper design and monitoring of the solid-state in pharmaceutical industry in order to fulfill the requirements of the guideline dealing with polymorphism of the International Conference of Harmonization.
Journal ArticleDOI
Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability
TL;DR: This review covers a comprehensive description of the CUR pharmaceutical solids, such as polymorphs, cocrystals, eutectics, and coamorphous solid-state forms with aim to determine ways to improve its physicochemical properties, including dissolution rate, solubility, physicochemical stability, mechanical strength, compressibility for tablet formation, and oral bioavailability.
Journal ArticleDOI
Investigation of piroxicam polymorphism
TL;DR: The polymorphism of piroxicam has been discussed by many authors, but it is still uncertain in how many polymorphic and pseudopolymorphic modifications it can exist.
Journal ArticleDOI
Application of attenuated total reflectance FTIR spectroscopy to the analysis of mixtures of pharmaceutical polymorphs
Amid Salari,Richard E Young +1 more
TL;DR: In this paper, the feasibility of the Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) to the qualitative and quantitative analysis of mixtures of polymorphs is investigated using three known polymorphs of ganciclovir as model compounds.
Journal ArticleDOI
Quantitative analysis of piroxicam polymorphs pharmaceutical mixtures by hyperspectral imaging and chemometrics
Werickson Fortunato de Carvalho Rocha,Guilherme P. Sabin,Paulo Henrique Março,Ronei J. Poppi +3 more
TL;DR: In this paper, the piroxicam polymorphic forms 1 and 2 were studied using near-infrared chemical imaging (NIR-CI) technology to map the distribution of both species in pharmaceutical formulations.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.