Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Preparation and characterization of amorphous, I and II forms of clopidogrel hydrogen sulfate
Jie Lu,Jing Wang,Sohrab Rohani +2 more
TL;DR: In this article, the amorphous, I and II forms of clopidogrel hydrogen sulfate (CHS) were prepared and characterized by use of powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC).
Journal ArticleDOI
Oriented Crystallization on Organic Monolayers to Control Concomitant Polymorphism
TL;DR: Functional self-assembled monolayer (SAM) of organic thiol on gold surface has been employed as an efficient approach to control concomitant nucleation of such flexible drug and emphasized.
Patent
Polymorph of 5-[4-[2-(N-Methyl-N-(2-Pyridyl)Amino)Ethoxy]Benzyl]Thiazolidine-2,4-Dione maleic acid salt
Paul David James GlaxoSmithKline Blackler,Browne Christine Marie,Coakley Timothy G,Giles Robert Gordon,Morrissey Gillian +4 more
TL;DR: A polymorphic form of 5-[4]-methyl-N-(2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt (the "Polymorph") characterised in that it provides: (i) an infra red spectrum containing peaks at 1763, 912, 856 and 709 cm-1; and/or (ii) a Raman spectrum containing peak at 1762, 1284, 9 12 and 888 cm- 1; and (iii)
Journal ArticleDOI
Isolation Strategies and Transformation Behaviors of Spironolactone Forms
TL;DR: In this paper, two new forms of spironolactone, 1-propanol solvate and 2Propanol Solvate, were found and characterized, and the thermodynamic stability and solubility of form II and four alcohol solvates of SPI were investigated and determined.
Journal ArticleDOI
Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil
TL;DR: In this paper, the dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States PharmacOPoeia, 2004) and then compared.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.