Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Dissertation
Role of hydrogen bonding lifetime and complementarity in heterogeneous nucleation
TL;DR: In this paper, the authors investigated the mechanism for the heterogeneous nucleation of active pharmaceutical ingredients (APIs) in the presence of different excipient heterosurfaces, and found that the hydrogen bonding lifetime of the individual API molecules or small API clusters attached to a heter-osurface is much longer than the lifetime of API-API interactions in the solution phase, or the time required for an API molecule to add to a solution phase.
Journal ArticleDOI
A New Hemihydrate of Valacyclovir Hydrochloride
TL;DR: Several crystal forms of valacyclovir hydrochloride, including two anhydrous and three hydrates, were investigated in this paper, and a new hemihydrate was first discovered and its properties were characterized by PXRD, TGA, DSC, and Raman.
Journal ArticleDOI
Evaluation of the Relative Stability of Toropane Derivative Nitrate Polymorphs
Journal ArticleDOI
A New, More Stable Polymorphic Form of Otilonium Bromide: Solubility, Crystal Structure, and Phase Transformation
TL;DR: Through thermal analysis and solubility experiments the relative stability of both crystal modifications were determined, confirming that at room temperature this new Form I is the more stable one, Form II existing just in a metastable state.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.