Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Solid state characterization of the anti-HIV drug TMC114: Interconversion of amorphous TMC114, TMC114 ethanolate and hydrate
Elke Van Gyseghem,Sigrid Carl Maria Stokbroekx,Hector Novoa de Armas,Jules Dickens,Marc Vanstockem,Lieven Baert,Jan Rosier,Laurent Schueller,Guy Van den Mooter +8 more
TL;DR: Whereas TMC114 ethanolate is stable in the commercialized drug product, special conditions can trigger its conversion, and the amorphous form, prepared by melting-quenching shows a limited water uptake.
Journal ArticleDOI
Polymorph Control of Micro/Nano-Sized Mefenamic Acid Crystals on Patterned Self-Assembled Monolayer Islands
TL;DR: In this article, patterned self-assembled monolayers (SAMs) are employed, on which a large number of identical experiments can be conducted and the results show that SAMs forming a strong interaction with the −COOH group of MA molecules preferably produced form II.
Journal ArticleDOI
Determination of the Crystal Structure of a New Polymorph of Theophylline
Mark D. Eddleston,Katarzyna E. Hejczyk,Erica G. Bithell,Graeme M. Day,Graeme M. Day,William Jones +5 more
TL;DR: A new approach to crystal structure determination, combining crystal structure prediction and transmission electron microscopy, was used to identify a potential new crystal phase of the pharmaceutical compound theophylline, despite the new polymorph occurring as a minor component in a mixture with Form II.
Journal ArticleDOI
Solid-state 13C NMR study of indomethacin polymorphism.
Katsuhiko Masuda,Sachio Tabata,Hiroyuki Kono,Yasuyuki Sakata,Tetsuo Hayase,Etsuo Yonemochi,Katsuhide Terada +6 more
TL;DR: It was found that solid-state (13)C NMR can be a powerful tool to estimate the number of molecular conformations as well as configurational differences in the packing of molecules in a unit cell.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.