Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates
TL;DR: In this paper, the authors present a review of the use of thermal analysis for the analysis of polymorphism and pseudo-polymorphism in drug substances and excipients, including solvates and impurities.
Journal ArticleDOI
Facts and fictions about polymorphism.
TL;DR: It is found that molecular flexibility or size has no correlation with the ability of a compound to be polymorphic and one in three compounds in the CSD are polymorphic whilst at least one in two compounds from the Roche and Lilly set display polymorphism with a higher estimate when compounds are screened intensively.
Journal ArticleDOI
Phase transformation considerations during process development and manufacture of solid oral dosage forms
TL;DR: The basic principles of polymorphism are reviewed, the classes of phase transformation and the underlying transformation mechanisms are defined, and respective kinetic factors are discussed.
Journal ArticleDOI
Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs
TL;DR: Chitosan microspheres were prepared by a novel precipitation process using sodium sulfate as precipitant in this paper, and the extent of precipitation was controlled by the concentration of Sodium sulfate and monitored by turbidity measurement.
Journal ArticleDOI
Using Terahertz Pulsed Spectroscopy to Quantify Pharmaceutical Polymorphism and Crystallinity
Clare J. Strachan,Philip F. Taday,David A. Newnham,Keith C. Gordon,J. Axel Zeitler,Michael Pepper,Thomas Rades +6 more
TL;DR: In this study, four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified, demonstrating that TPS is an analytical technique of potential in quantifying solid- state properties of pharmaceutical compounds.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.