Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Early development evaluation of AZD2738, a substrate for the NK receptors
TL;DR: Investigation of whether AZD2738, a dual neurokinin NK1/2 receptor antagonist, is a suitable candidate for further development with an oral immediate release solid dosage form as a possible final product finds the chloride salt is preferred for continued product development.
Journal ArticleDOI
Infrared spectroscopic and thermal analysis of different modifications of calcium valproate
G.N. Kalinkova,St.I. Hristov +1 more
TL;DR: In this article, the authors used infrared spectroscopy and thermal analysis to characterize and compare calcium valproate (a compound demonstrating antiepileptic properties) with its different crystalline modifications.
Patent
Crystal modification of mesotrione
Carmen Cohen,Maidan Ruben +1 more
TL;DR: In this paper, a crystalline polymorph Form 3 of 2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione is described.
Patent
Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
TL;DR: The present paper relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases.
Journal ArticleDOI
Vibrational and thermal characterisation of a new chiral drug under investigation for the therapy of congestive heart failure
TL;DR: In this paper, Raman and IR spectroscopies coupled with thermal analysis were used for investigating the presence of different polymorphic forms, their relative stability and interconversion tendency in relation to industrial manufacturing processes undergone by the drug (i.e. grinding, compression, heating).
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.