Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Synthesis and biological evaluation of orally active hypolipidemic agents.
Babasaheb P. Bandgar,Rajendra J. Sarangdhar,Fruthous Khan,Jeyamurugan Mookkan,Pranesha Shetty,Gajendra Singh +5 more
TL;DR: Fenofibric acid ester prodrugs 1c-1h emerged as potent hypolipidemic agents on the basis of in vivo studies, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice.
Journal ArticleDOI
Effect of polymorphism on thermodynamic properties of cefamandole nafate
TL;DR: In this paper, the effect of polymorphism on thermodynamic properties of cefamandole nafate was investigated in detail by using powder X-ray diffraction and differential scanning calorimetry (DSC).
Journal ArticleDOI
Application of a novel combination of near-infrared spectroscopy and a humidity-controlled 96-well plate to the characterization of the polymorphism of imidafenacin
TL;DR: A currently available chemometric near‐infrared spectroscopy technique is applied to the characterization of the polymorphic properties of drug candidates and is applicable to drugs in the early stages of development.
Journal ArticleDOI
Design and molecular insights of drug-active metabolite based co-amorphous formulation: a case study of toltrazuril-ponazuril co-amorphous
TL;DR: In this article , the potential for active metabolites of drugs as co-former in drug-drug co-amorphous formulations was assessed, and the solubility/dissolution and solid-state stability of the coamorphous system were investigated.
Journal ArticleDOI
Influence of polymeric excipient properties on crystal hydrate formation kinetics of caffeine in aqueous slurries
TL;DR: The influence of polymeric excipients on the hydrate transformation of caffeine (CAF) was studied and a pH dependence was observed: at low pH, the inhibition was greatest, whereas no inhibitory effects were observed at pH above 6.5.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.