Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Journal ArticleDOI
Five Cocrystal Forms of Antitumor Drug Temozolomide with p-Hydroxybenzoic Acid: Structure, Computational Analysis, Characterizations, Stability, and Transformation
Hongmei Yu,Baoxi Zhang,Wenhui Xing,Meiju Liu,Dezhi Yang,Guorong He,Feng-Feng Wang,Bing Zhang,Ningbo Gong,Yang Lu,Guanhua Du +10 more
TL;DR: In this article , cocrystallization of TMZ with p-hydroxybenzoic acid (PHBA) produced five forms including one methanolate, one hydrate, two polymorphic forms in 2:1, and one solvent-free form in 1:1 ratio.
OtherDOI
Physicochemical Characterization and Oral Dosage Form Design and Selection
Patent
Polymorphs of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phyenyl}-3-methoxyacrylate
Sharona Zamir,Faktorovitch Inna +1 more
TL;DR: In this paper, the authors proposed a method for the synthesis of polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin).
Patent
Crystalline form of fosinopril calcium
TL;DR: Novel crystalline form of fosinopril calcium, process for its preparation, pharmaceutical compositions and use thereof in therapy as discussed by the authors, is described in detail in the paper.
Patent
Procede de preparation de risperidone ameliore
TL;DR: The authors concerne un procede permettant de produire une risperidone representee par la formule (I) which consiste: a) faire reagir un compose halo avec un oxime dans un solvant and une base a 10-40 °C; a soumettre le melange de reaction obtenu a l'etape (a) a reflux pendant 4 a 10 heures; c) a ajouter une base au melange refroidit soumis a un reflux a l
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.