Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Book ChapterDOI
Utilization of biopharmaceutical and pharmacokinetic principles in the development of veterinary controlled release drug delivery systems
TL;DR: The aim of this chapter is to provide an overview of biopharmaceutical and pharmacokinetic principles that are essential in meeting the challenges facing innovative producers of veterinary controlled release products on two major veterinary markets: livestock and companion animals.
Journal ArticleDOI
High-pressure Nucleation of Low-Density Polymorphs*.
TL;DR: In this paper, the authors showed that bis-3-nitrophenyl disulphide is less dense than the ambient-pressure polymorph α and β, and that pressure compensates the high entropy and temperature product, substantiated in varied conformers and increased chemical potential.
Journal ArticleDOI
Solid state modifications of drospirenone
TL;DR: In this article, structural, thermal and spectroscopic characterization of two different solid state forms of drospirenone (C24 H30 O3), a crystalline phase and an amorphous one were presented.
Journal ArticleDOI
H/D Isotope Effects on the Short O–H···O Hydrogen Bond Geometries and Temperature-Dependent Polymorphism of Two Organic Salts Containing Hydrogen 2,3,5,6-Tetrafluorophthalate Monoanions
Journal ArticleDOI
Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy.
Partha Pratim Das,Giulio Guzzinati,C. Coll,Alejandro Gómez Pérez,Stavros Nicolopoulos,Sònia Estradé,Francesca Peiró,Johan Verbeeck,Aikaterini A. Zompra,Athanassios S. Galanis +9 more
TL;DR: Electron energy loss spectroscopy at high energy resolution by transmission electron microscope (TEM) is expected to be a promising technique to screen and identify the different (organic) compounds used in a typical pharmaceutical or biological system and to detect any impurities present, if any, during the synthesis or formulation process.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.