Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Journal ArticleDOI
Reversible phase transitions in a buckybowl monolayer.
Leo Merz,Manfred Parschau,Laura Zoppi,Kim K. Baldridge,Jay S. Siegel,Karl-Heinz Ernst,Karl-Heinz Ernst +6 more
TL;DR: Like penguins on ice, buckybowl molecules move closer together when cooled on a copper surface (see model of a corannulene molecule adsorbed on Cu(111) for a model of how this affects the density at room temperature.
Journal ArticleDOI
Ab initio prediction of polymorphs
TL;DR: The prediction of possible crystal structures from first principles, using only the molecular structure as a starting point, is still controversial as mentioned in this paper, and an approach to solving this crystal packing problem has been proposed.
Journal ArticleDOI
Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies.
TL;DR: This study generated a model tablet system with two excipients and a 10% API concentration, where the API is a mixture of the FII and FIII polymorphs of piracetam, and using transmission Raman spectroscopy (TRS) and NIR spectroscopies it was possible to detect FII polymorph contamination in these model tablets.
Journal ArticleDOI
Micronisation of carbamazepine through rapid expansion of supercritical solution (RESS)
Dennis Bolten,Michael Türk +1 more
TL;DR: In this paper, the formation of submicron carbamazepine particles by rapid expansion of supercritical solutions (RESS) was reported, and the results showed that the particle size can be reduced at least by a factor of 29 to median sizes between 0.43 and 0.9μm.
Journal ArticleDOI
Fresemide crystal forms; solid state and physicochemical analyses
Christopher Doherty,Peter York +1 more
TL;DR: In this article, the formation of diuretic frusemide II was shown to be solvent dependent, being recrystallised by a solvent-evaporation process from methanol or ethanol and inhibited by the addition of water (5% v/v level).
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.