Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
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Journal ArticleDOI
Cocrystals of the Tuberculosis Drug Isoniazid: Polymorphism, Isostructurality, and Stability
TL;DR: In this article, a cocrystal screen with pharmaceutically acceptable molecules selected from the generally regarded as safe (GRAS) was performed to improve the physiochemical properties of Isoniazid.
Journal ArticleDOI
A material science perspective of pharmaceutical solids.
TL;DR: This review introduces the basic material science concepts and principles behind some common topics in the development of pharmaceutical solid formulations, and potential energy states of different phases are highlighted as the key connection between the physical nature of the materials and their pharmaceutical behavior.
Patent
Crystalline forms of a bruton's tyrosine kinase inhibitor
TL;DR: The Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-( 4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin]-prop-2-en-one, including crystalline forms, solvates and pharmaceutically acceptable salts thereof, is described in this article, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for
Journal ArticleDOI
Pharmaceutical Liquid Crystals: The Relevance of Partially Ordered Systems
TL;DR: The general structural characteristics that favor the formation of liquid crystalline mesophases are categorized by therapeutic target and molecular size, and the analytical means of their identification are presented.
Journal ArticleDOI
A prolific solvate former, galunisertib, under the pressure of crystal structure prediction, produces ten diverse polymorphs
Rajni M. Bhardwaj,Jennifer A. McMahon,Jonas Nyman,Jonas Nyman,Louise S. Price,Sumit Konar,Iain D. H. Oswald,Colin R. Pulham,Sarah L. Price,Susan M. Reutzel-Edens +9 more
TL;DR: The crystal structures of all 10 unsolvated polymorphs of galunisertib are presented, showing how state-of-the-art characterization methods can be combined with emerging computational modelling techniques to produce a complete structure landscape and assess the risk of late appearing, more stable polymorphs.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.