Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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Kinetic study of the transformation from tetrahydrate to monohydrate of a new antiallergic, sodium 5-(4-oxo-phenoxy-4H-quinolizine-3-carboxamide)-tetrazolate.
TL;DR: Two hydrates (tetrahydrate, I, and monohydrate, II) of a new antiallergic, sodium 5-(4-oxo-phenoxy-4H-quinolizine-3-carbox-amide)-tetrazolate were prepared and characterized by means of infrared spectrometry, thermal analysis, and power X-ray diffraction spectromaetry.
Journal ArticleDOI
Electropolymerizable N-heterocyclic carbene complexes of Rh and Ir with enantiotropic polymorphic phases.
TL;DR: New Rh (1) and Ir (2) complexes of an N-heterocyclic carbene (NHC) featuring a terthiophene backbone were synthesized, revealing two enantiotropic polymorphic phases with similar lattice parameters for each compound.
Journal ArticleDOI
FT-IR spectrophotometric analysis of dehydroepiandrosterone and its pharmaceutical formulation.
TL;DR: A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of dehydropeiandrosterone and the best results were obtained with PCR+ method.
Journal ArticleDOI
A Truly Polymorphic Issue in Honor of Prof Joel Bernstein
Patent
Crystalline forms of n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl] thio]-2-thiazolyl]-4-piperidinecarboxamide
TL;DR: In this article, a pharmaceutical composition comprising one or more crystalline forms of N-[5-[[[5-(l,l-dimethylethyl)- 2-oxazolyl]metliyl]thio]-2-thiazolyl]-4-piperidinecarboxamide was presented.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.