Journal ArticleDOI
Pharmaceutical Applications of Polymorphism
John K. Haleblian,Walter McCrone +1 more
TLDR
Polymorphism is the ability of any element or compound to crystallize as more than one distinct crystal species (e.g., carbon as cubic diamond or hexagonal graphite).About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1969-08-01. It has received 894 citations till now. The article focuses on the topics: Polymorphism (materials science) & Crystal.read more
Citations
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An accurate quantitative analysis of polymorphs based on artificial neural networks
TL;DR: The two diffraction peaks selected as the best combination in multiple linear regression were used in the ANN with an extended Kalman filter as a training algorithm and the results obtained had better predictive accuracy at lower contents compared to those of MLR.
Journal ArticleDOI
Polymorphic Characterization of Pharmaceutical Solids, Donepezil Hydrochloride, by 13 C CP/MAS Solid-State Nuclear Magnetic Resonance Spectroscopy
TL;DR: In this article, four different forms of donepezil hydrochloride were prepared and characterized using X-ray powder diffraction, Fourier transform infrared, and solid-state nuclear magnetic resonance (NMR) spectroscopy.
Journal ArticleDOI
Preliminary studies on unusual polymorphs of thymine: Structural comparison with other nucleobases
Ramanaiah Chennuru,Ramanaiah Chennuru,Prakash Muthudoss,Srividya Ramakrishnan,Amjad Basha Mohammad,R. Ravi Chandra Babu,Sudarshan Mahapatra,Susanta K. Nayak +7 more
TL;DR: Two polymorphs of anhydrous thymine, Form-R2 and FormR4, were obtained via sublimation crystallization and desolvation technique respectively as discussed by the authors.
Journal ArticleDOI
Physical Characterization of Two Oxyphenbutazone Pseudopolymorphs
TL;DR: The dissolution rates of the two pseudopolymorphic forms of oxyphenbutazone were shown to be superior to those of the anhydrate, hemihydrate, and monohydrate which were previously reported.
Journal ArticleDOI
Amorphous pharmaceutical solids.
TL;DR: The properties of amorphous materials can be exploited to improve the performance of pharmaceutical dosage forms, but these properties can also give rise to unwanted effects that need to be understood and managed in order for the systems to perform as required.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
The united states pharmacopeia.
TL;DR: The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.
Book
Thermal methods of analysis
TL;DR: In this article, a revised edition necessitated by the phenomenal growth of the field during the past decade contains 90% new material, focusing on tech niques and applications of thermal analysis.